Nanoplastic Bioaccumulation Model: From Fish to Human Brain
Analysis
Key Takeaways
- •A unified toxicokinetic model is developed to predict nanoplastic bioaccumulation.
- •Dietary intake is identified as the dominant pathway for human exposure.
- •Brain emerges as a dominant sink due to lipid-mediated enrichment.
- •The model bridges short-term animal experiments and chronic human bioaccumulation.
“At steady state, human organ concentrations follow a robust cubic scaling with tissue lipid fraction, yielding blood-to-brain enrichment factors of order $10^{3}$--$10^{4}$.”