Dynamic Phenotypes and Model Discrimination in Systems Biology
Analysis
Key Takeaways
- •Focus on transient dynamics is crucial for understanding biological networks.
- •Dynamic phenotypes like overshoots and adaptation kinetics are key.
- •Sign structure and interconnection logic are important for model discrimination.
- •Control-theoretic concepts can be used as mathematical tools.
- •Input-driven dynamics are essential for reverse-engineering.
“The paper argues for a shift in emphasis from asymptotic behavior to transient and input-driven dynamics as a primary lens for understanding, testing, and reverse-engineering biological networks.”