Constraints on Perfect Phylogeny Mixture Model to Reduce Ambiguity
Analysis
Key Takeaways
- •The PPM model suffers from significant ambiguity, leading to multiple possible phylogenetic trees for the same data.
- •Existing longitudinal constraints are shown to be ineffective in reducing this ambiguity.
- •The paper proposes and analyzes novel constraints to mitigate the ambiguity.
- •The analysis uses an ensemble-based theoretical framework, providing results applicable to a wide range of inference problems.
“The paper proposes novel alternative constraints to limit solution ambiguity and studies their impact when the data are observed perfectly.”