Research Paper#Epigenetics, Gene Regulatory Networks, Theoretical Biology🔬 ResearchAnalyzed: Jan 3, 2026 09:29
Epigenetic Control of Gene Regulatory Networks: A Theoretical Approach
Published:Dec 30, 2025 19:06
•1 min read
•ArXiv
Analysis
This paper introduces a theoretical framework to understand how epigenetic modifications (DNA methylation and histone modifications) influence gene expression within gene regulatory networks (GRNs). The authors use a Dynamical Mean Field Theory, drawing an analogy to spin glass systems, to simplify the complex dynamics of GRNs. This approach allows for the characterization of stable and oscillatory states, providing insights into developmental processes and cell fate decisions. The significance lies in offering a quantitative method to link gene regulation with epigenetic control, which is crucial for understanding cellular behavior.
Key Takeaways
- •Develops a theoretical framework using Dynamical Mean Field Theory to model gene regulatory networks with epigenetic modifications.
- •Provides a quantitative method to link gene regulatory dynamics with epigenetic control.
- •Offers insights into developmental processes and cell fate decisions by characterizing stable and oscillatory states.
Reference
“The framework provides a tractable and quantitative method for linking gene regulatory dynamics with epigenetic control, offering new theoretical insights into developmental processes and cell fate decisions.”