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This paper introduces CENNSurv, a novel deep learning approach to model cumulative effects of time-dependent exposures on survival outcomes. It addresses limitations of existing methods, such as the need for repeated data transformation in spline-based methods and the lack of interpretability in some neural network approaches. The paper highlights the ability of CENNSurv to capture complex temporal patterns and provides interpretable insights, making it a valuable tool for researchers studying cumulative effects.
Reference

CENNSurv revealed a multi-year lagged association between chronic environmental exposure and a critical survival outcome, as well as a critical short-term behavioral shift prior to subscription lapse.