Research Paper#Drug Delivery, Controlled Release, Microparticles🔬 ResearchAnalyzed: Jan 3, 2026 09:18
Interfacial Diffusion Control in Micro-Particle Release
Analysis
This paper investigates how the coating of micro-particles with amphiphilic lipids affects the release of hydrophilic solutes. The study uses in vivo experiments in mice to compare coated and uncoated formulations, demonstrating that the coating reduces interfacial diffusivity and broadens the release-time distribution. This is significant for designing controlled-release drug delivery systems.
Key Takeaways
- •The study focuses on the interfacial transport problem in micro-particle formulations.
- •Coating micro-particles with amphiphilic lipids can control the release of hydrophilic solutes.
- •In vivo experiments in mice are used to validate the findings.
- •The coating reduces interfacial diffusivity and broadens the release-time distribution.
- •The research has implications for designing controlled-release drug delivery systems.
Reference
“Late time levels are enhanced for the coated particles, implying a reduced effective interfacial diffusivity and a broadened release-time distribution.”